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Chemical Structure : YUM70
CAS No.: 423145-35-1
Catalog No.: PC-72448Not For Human Use, Lab Use Only.
YUM70 (YUM-70) is a derivative of 8-hydroxyquinoline targeting GRP78, and cytotoxic to pancreatic cancer cell lines (MIA PaCa-2 cell IC50=2.5 uM).
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| 25 mg | $358 | In stock | |
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YUM70 (YUM-70) is a derivative of 8-hydroxyquinoline targeting GRP78, and cytotoxic to pancreatic cancer cell lines (MIA PaCa-2 cell IC50=2.5 uM).
YUM70 dose-dependently decreased PANC-1 and UM59 cell proliferation in 3D-culture systems (IC50<10 uM).
YUM70 upregulates UPR target proteins and induces ER stress and apoptosis via phosphorylation of eIF2α.
YUM70 binds to full-length GRP78 and causes a positive shift in the melting temperature (Tm) of GRP78 in a dose-dependent manner.
YUM70 inhibits GRP78 ATPase activity of the full-length protein with IC50 of 1.5 uM.
YUM70 can up-regulate GRP78 transcription and protein levels.
YUM70 reduces tumor growth in a MIA PaCa-2 xenograft model.
| M.Wt | 398.843 | |
| Formula | C21H19ClN2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(benzo[d][1,3]dioxol-5-yl(5-chloro-8-hydroxyquinolin-7-yl)methyl)butyramide |
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1. Soma Samanta, et al. Cancer Res. 2021 Apr 1;81(7):1883-1895.
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