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Chemical Structure : YW3-56
Catalog No.: PC-35354Not For Human Use, Lab Use Only.
YW3-56 is a potent peptidylarginine deiminase (PAD) inhibitor with inhibitory activity against PAD2 (IC50=0.5-1 uM) and PAD4 (IC50=1-2 uM), inhibits U2OS cancer cell growth with IC50 of 2.5 uM.
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YW3-56 is a potent peptidylarginine deiminase (PAD) inhibitor with inhibitory activity against PAD2 (IC50=0.5-1 uM) and PAD4 (IC50=1-2 uM), inhibits U2OS cancer cell growth with IC50 of 2.5 uM.
YW3-56 activates a cohort of p53 target genes, including SESN2, which in turn inhibits the mTORC1 signaling pathway, thereby perturbing autophagy and inhibiting cancerous cell growth, effectively inhibits the growth of triple-negative breast cancer xenograft tumors in nude mice。
YW3-56 also significantly blocks LPS-induced pulmonary vascular leakage, alleviates acute lung injury, and improves survival in mouse model of lethal LPS-induced endotoxemia.
| M.Wt | 494.036 | |
| Formula | C27H32ClN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang Y, et al. J Biol Chem. 2012 Jul 27;287(31):25941-53.
2. Wang S, et al. Mol Cancer Ther. 2015 Apr;14(4):877-88.
3. He W, et al. J Surg Res. 2016 Feb;200(2):610-8.
4. Liang Y, et al. Eur J Pharmacol. 2018 Jul 4. pii: S0014-2999(18)30372-8.
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