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Chemical Structure : YZ129
CAS No.: 1643120-60-8
Catalog No.: PC-35998Not For Human Use, Lab Use Only.
YZ129 (YZ-129) is a small molecule inhibitor of HSP90-Calcineurin-NFAT pathway, suppresses TG-induced NFAT nuclear translocation in HeLa cellswith IC50 of 820 nM.
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|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $238 | In stock | |
| 100 mg | Get quote |
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YZ129 (YZ-129) is a small molecule inhibitor of HSP90-Calcineurin-NFAT pathway, suppresses TG-induced NFAT nuclear translocation in HeLa cellswith IC50 of 820 nM.
YZ129 also suppressed the expression of NFAT-regulated genes, such as COX2, MMP7, and MMP9, in U87 GBM cells.
YZ129 directly binds to HSP90 to antagonize its chaperoning effect on calcineurin, a Ca2+-sensitive phosphatase that is required for NFAT nuclear translocation and subsequent gene expression.
YZ129 could not only suppress cancer cell growth but also reduce cancer cell movement and migration of of GBM cells in vitro.
YZ129 suppresses the growth of GBM xenografts in vivo.
| M.Wt | 300.317 | |
| Formula | C19H12N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(isoquinolin-6-ylamino)naphthalene-1,2-dione |
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1. Liu Z, et al. Cell Chem Biol. 2018 Nov 30. pii: S2451-9456(18)30431-8.
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