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Chemical Structure : Yanostat
Catalog No.: PC-20992Not For Human Use, Lab Use Only.
Yanostat (KH16) is a novel potent HDAC inhibitor with low nanomolar in vitro activity against class I HDACs (HDAC1/2/3 IC50=13/34/6 nM).
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Yanostat (KH16) is a novel potent HDAC inhibitor with low nanomolar in vitro activity against class I HDACs (HDAC1/2/3 IC50=13/34/6 nM).
Yanostat (KH16) is less active against the class I HDAC HDAC8 (IC5-=530 nM) and the class IIB HDAC HDAC6 (IC50=460 nM), and has far weaker activity against the class IV HDAC HDAC11 (IC50=870 nM).
Yanostat (KH16) induces apoptosis of HEL erythroleukemia cells with IC50 of 110 nM, which is significantly more effective than SAHA.
Yanostat (KH16) (100 nM) induces accumulation of the acetylated histones H3 and H4, KH16 causes cell cycle arrest and DNA fragmentation.
Yanostat (KH16) dysregulates apoptosis regulators and modulates autophagy and apoptosis in leukemic cells.
| M.Wt | 352.40 | |
| Formula | C18H20N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Fischer MA, et al. J Adv Res. 2023 Jul 17:S2090-1232(23)00197-2.
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