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Chemical Structure : Yonkenafil
Catalog No.: PC-38810Not For Human Use, Lab Use Only.
Yonkenafil is a potent, selective PDE5 inhibitor with IC50 of 2.0 nM.
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Yonkenafil is a potent, selective PDE5 inhibitor with IC50 of 2.0 nM.
Yonkenafil inhibits microglial activation by decreasing PDE-5 expression and increasing the cGMP level.
Yonkenafil induces neuronal network potentiation by a cGMP-dependent Nogo-R axis in acute experimental stroke.
Yonkenafil modulates neurogenesis, gliosis to improve cognitive function and ameliorates amyloid burden in an APP/PS1 transgenic mice model.
| M.Wt | 487.619 | |
| Formula | C24H33N5O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chen X, et al. Exp Neurol. 2014 Nov;261:267-77.
2. Zhu L, et al. Mech Ageing Dev. 2015 Sep;150:34-45.
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