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Z-VEID-FMK

Chemical Structure : Z-VEID-FMK

CAS No.: 210344-96-0

Z-VEID-FMK (Z-VE(OMe)ID(OMe)-FMK)

Catalog No.: PC-25487Not For Human Use, Lab Use Only.

Z-VEID-FMK (Z-VE(OMe)ID(OMe)-FMK) is a specific, irreversible caspase-6 inhibitor, mimicks the effects of caspase-6 deficiency and prevents the cleavage of lamin A, significantly decreases caspase-6 activity and the oxLDL-induced DNA fragmentation and cell apoptosis. 

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Z-VEID-FMK (Z-VE(OMe)ID(OMe)-FMK) is a specific, irreversible caspase-6 inhibitor, mimicks the effects of caspase-6 deficiency and prevents the cleavage of lamin A, significantly decreases caspase-6 activity and the oxLDL-induced DNA fragmentation and cell apoptosis. 

Physicochemical Properties

M.Wt 652.72
Formula C31H45FN4O10
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

L-Isoleucinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-L-α-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, methyl ester

References

1. Gregoli PA, et al. J Cell Physiol. 1999 Feb;178(2):133-43.

2. Ruchaud S, et al. EMBO J. 2002 Apr 15;21(8):1967-77.

3. Philippe P Monnier, et al. J Neurosci. 2011 Jul 20;31(29):10494-505.

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