Chemical Structure : Z8526711350
CAS No.:
3069879-24-6 (Rac)
Z8526711350
(CB1R agonist '1350)
Catalog No.: PC-24486Not For Human Use, Lab Use Only.
Z8526711350 (CB1R agonist '1350) is a potent, specific agonist of cannabinoid-1 receptor (CB1R) with Ki of 0.95 nM, is a full agonist of CB1R-mediated Gi/o signaling.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Z8526711350 (CB1R agonist '1350) is a potent, specific agonist of cannabinoid-1 receptor (CB1R) with Ki of 0.95 nM, is a full agonist of CB1R-mediated Gi/o signaling.
'1350 shows no strong functional selectivity or bias but is both more potent and relatively more efficacious than CP-55,940 at CB1R but not CB2R.
'1350 is approximately 2-fold more relatively efficacious at recruiting Gi/o and G13 subtypes in CB1R than CP-55,940.
'1350 is strongly analgesic in male mice, with a 2-20-fold therapeutic window over hypolocomotion, sedation, and catalepsy and no observable conditioned place preference.
Physicochemical Properties
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M.Wt
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437.44
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Formula
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C20H18F3N3O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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methyl (R)-2-(5-methyl-1-(3-(trifluoromethyl)phenyl)-1H-pyrazole-3-carboxamido)-2-(thiophen-2-yl)propanoate
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References
1. Tummino TA, et al. Nat Commun. 2025 Mar 6;16(1):2237.
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