ZAP180013 | Zap70 inhibitor, NLRP3 inhibitor

Chemical Structure : ZAP-180013

CAS No.: 873080-25-2

ZAP-180013 (ZAP180013)

Catalog No.: PC-38018Not For Human Use, Lab Use Only.

ZAP-180013 (ZAP180013) is a small molecule inhibitor of zeta-chain-associated protein kinase 70 (Zap70) with IC50 of 1.8 uM (fluorescence polarization assay).

Packing	Price	Stock
5 mg	$58	In stock
10 mg	$88	In stock
25 mg	$148	In stock
50 mg	$238	In stock
100 mg		Get quote

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Biological Activity

ZAP-180013 (ZAP180013) is a small molecule inhibitor of zeta-chain-associated protein kinase 70 (Zap70) with IC50 of 1.8 uM (fluorescence polarization assay).

ZAP-180013 inhibits the interaction of Zap70 SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs), within the T-cell antigen receptor (TCR) signaling pathway.

ZAP-180013 also is a potent and selective inhibitor of NLRP3, interacts with histidine 698 (H698) in NLRP3.

ZAP-180013 effectively inhibits inflammasome activation in human myeloid cells, including those carrying MCC950-resistant NLRP3 mutations.

ZAP-180013 ameliorated psoriasiform skin inflammation and protected against lipopolysaccharide (LPS)-induced cytokine responses in mice.

Physicochemical Properties

M.Wt	454.32
Formula	C19H17Cl2N3O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-Chloro-N-[(4-chlorophenyl)methyl]-2-(ethylsulfonyl)-N-(2-furanylmethyl)-4-pyrimidinecarboxamide

References

1. Patrick R Visperas, et al. SLAS Discov. 2017 Mar;22(3):324-331.
2. Kim W, et al. Cell Chem Biol. 2025 Sep 9:S2451-9456(25)00259-4.

ZAP-180013 (ZAP180013)

Biological Activity

Physicochemical Properties

References

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