Chemical Structure : ZD-4009
CAS No.:
3120519-42-5
ZD-4009
(ZD4009)
Catalog No.: PC-28109Not For Human Use, Lab Use Only.
ZD-4009 is a potent and selective inhibitor of B-cell lymphoma 9 (BCL9), shows high-affinity binding to β-catenin with KD of 44.72 nM, shows antifibrotic efficacy.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ZD-4009 is a potent and selective inhibitor of B-cell lymphoma 9 (BCL9), shows high-affinity binding to β-catenin with KD of 44.72 nM, shows antifibrotic efficacy.
ZD-4009 inhibited fibroblast activation, suppressed extracellular matrix deposition, and reduced the expression of fibrosis-associated markers, including collagen type I alpha 1 chain (COL1A1) and alpha-smooth muscle actin (α-SMA).
ZD-4009 suppresses HIF-1α-associated glycolytic reprogramming and inhibits transforming growth factor-β (TGF-β)/SMAD family member (SMAD) signaling.
ZD-4009 suppresses fibroblast proliferation and extracellular matrix deposition in idiopathic pulmonary fibrosis.
ZD-4009 shows favorable antifibrotic effects compared with nintedanib.
Physicochemical Properties
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M.Wt
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468.56
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Formula
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C27H28N6O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(4-((5-(2-aminoethoxy)-4-(pyrrolidin-1-yl)pyrimidin-2-yl)amino)phenyl)-1-naphthamide
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References
1. Li A, et al. Mol Pharmacol. 2026 Jul 24;108(9):100144.
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