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Chemical Structure : ZH07
Catalog No.: PC-73236Not For Human Use, Lab Use Only.
ZH07 (Dual Mcl-1/Bfl-1 inhibitor 24) is a potent, selective dual Mcl-1 and Bfl-1 inhibitor, binds both Mcl-1 and Bfl-1 with Ki of 97 nM and 100 nM, respectively.
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ZH07 (Dual Mcl-1/Bfl-1 inhibitor 24) is a potent, selective dual Mcl-1 and Bfl-1 inhibitor, binds both Mcl-1 and Bfl-1 with Ki of 97 nM and 100 nM, respectively.
ZH07 displays appreciable selectivity (>250-fold) over Bcl-2/Bcl-xL.
ZH07 induces dose-dependent disruption of interactions between BL-Bim and endogenous Mcl-1 and Bfl-1, without affecting the complexes between BL-Bim and Bcl-2 or Bcl-xL.
ZH07 demonstrates on-target cellular activity in model lymphoma cell lines.
| M.Wt | 567.763 | |
| Formula | C30H37N3O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Xuexin Feng, et al. European Journal of Medicinal Chemistry 236 (2022) 114327
2. Karson J Kump, et al. J Med Chem. 2020 Mar 12;63(5):2489-2510.
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