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ZHSI-1

Chemical Structure : ZHSI-1

CAS No.: 2925912-67-8

ZHSI-1

Catalog No.: PC-21422Not For Human Use, Lab Use Only.

ZHSI-1 is a novel inhibitor of Enterovirus 71 (EV71) and Coxsackie A16 (CVA16) replication, interacts with 3D and potently inhibits EV71-induced cell death with IC50 of 3.27 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ZHSI-1 is a novel inhibitor of Enterovirus 71 (EV71) and Coxsackie A16 (CVA16) replication, interacts with 3D and potently inhibits EV71-induced cell death with IC50 of 3.27 uM.
ZHSI-1 significantly reduced EV71 and CVA16 RNA replication and viral titers in a dose-dependent manner in infected RD cells.
ZHSI-1 significantly inhibits the localization of 3D and PI4KB on the lysosomal surface and inhibited the colocalization of 3D and RagB.
ZHSI-1 also inhibits EV71-induced pyroptosis in EV71-infected RD cells.
ZHSI-1 Hcl (30 mg/kg) inhibits EV71 replication and viral pathogenesis in EV71-695F-infected mice, efficiently reduces the levels of EV71-695F RNA in the liver, brain, and muscles of mice.

Physicochemical Properties

M.Wt 293.37
Formula C17H19N5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N2-isopropyl-6-methyl-N4-(quinolin-6-yl)pyrimidine-2,4-diamine

References

1. Wang X, et al. J Cell Biol. 2023 Dec 4;222(12):e202303108.

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