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Chemical Structure : ZINC16991592
CAS No.: 422274-45-1
Catalog No.: PC-38067Not For Human Use, Lab Use Only.
ZINC16991592 (ZINC1592) is a selective MRGPRX2 antagonist with Ki of 189 nM.
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| 5 mg | $398 | In stock | |
| 10 mg | $598 | In stock | |
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ZINC16991592 (ZINC1592) is a selective MRGPRX2 antagonist with Ki of 189 nM.
ZINC16991592 completely inhibits the degranulation of human cord blood-derived MCs (hCMCs) induced by basic secretagogues and pseudoallergic drug, icatibant (Cat. PC-45267).
ZINC16991592 markedly inhibits the de novo synthesis of substance P (SP)-induced prostaglandin D2 in hCMCs.
ZINC16991592 inhibit p42/44 mitogen-activated protein kinase signal in hCMCs activated by SP.
| M.Wt | 269.322 | |
| Formula | C14H11N3OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-(pyridin-2-ylmethyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one |
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1. Can Cao, et al. Nature. 2021 Dec;600(7887):170-175.
2. Hiroyuki Ogasawara, et al. J Leukoc Biol. 2019 Nov;106(5):1069-1077.
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