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Chemical Structure : ZINC20451377
CAS No.: 2306303-35-3
Catalog No.: PC-38657Not For Human Use, Lab Use Only.
ZINC20451377 is a small molecule that binds to hepatitis B surface antigen (HBsAg) with high affinity (Kd=65.3 nM), reduces HBsAg levels and HBV virion secretion in cell culture model for HBV.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $298 | In stock | |
| 5 mg | $488 | In stock | |
| 10 mg | $758 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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ZINC20451377 is a small molecule that binds to hepatitis B surface antigen (HBsAg) with high affinity (Kd=65.3 nM), reduces HBsAg levels and HBV virion secretion in cell culture model for HBV.
ZINC20451377 effectively inhibits both WT HBV (IC50=9.7 uM) and tenofovir-resistant HBV.
ZINC20451377 inhibits HBsAg and virion secretion in some of the clinically relevant drug-resistant HBV mutants.
| M.Wt | 526.681 | |
| Formula | C32H38N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-(4-methoxyphenyl)-1-(4-(3-((4-(pyridin-3-ylmethyl)piperazin-1-yl)methyl)phenoxy)piperidin-1-yl)prop-2-en-1-one |
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1. S Kiruthika, et al. Sci Rep. 2021 Jun 3;11(1):11723.
2. S Kiruthika, et al. J Antimicrob Chemother. 2022 May 6;dkac148.
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