Chemical Structure : ZK-316
CAS No.:
3027894-30-7
ZK-316
(ZK316)
Catalog No.: PC-24427Not For Human Use, Lab Use Only.
ZK-316 is a potent, HIV non-nucleoside reverse transcriptase inhibitor (NNRTI) with IC50 of 0.21 uM (WT HIV-1 RT), exhibits potent and broad-spectrum activity against wild-type and clinically observed mutant strains with EC50 of 0.99-75.1 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ZK-316 is a potent, HIV non-nucleoside reverse transcriptase inhibitor (NNRTI) with IC50 of 0.21 uM (WT HIV-1 RT), exhibits potent and broad-spectrum activity against wild-type and clinically observed mutant strains with EC50 of 0.99-75.1 nM.
ZK-316 exhibits the highest inhibitory activity against WT HIV-1 (EC50 = 0.99 nM) and selectivity index (SI > 227,273).
ZK-316 is exceptionally potent against single/double mutant strains with EC50 values of 2.61 nM (L100I), 1.13 nM (K103N), 5.86 nM (Y181C), 5.18 nM (Y188L), 7.75 nM (E138 K), 4.46 nM (F227L + V106A), and 75.1 nM (RES056) in MT-4 cells.
ZK-316 shows favorable pharmacokinetic profiles with a better oral bioavailability of 29%.
Physicochemical Properties
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M.Wt
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554.72
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Formula
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C27H22D6N6O3S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-((4-((4-(4-Cyano-2,6-bis(methyl-d3)phenoxy)thieno[3,2-d]pyrimidin-2-yl)amino)piperidin-1-yl)methyl)benzenesulfonamide
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References
1. Kun Zhang, et al. J Med Chem. 2025 Apr 5. doi: 10.1021/acs.jmedchem.5c00202.
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