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ZLN-005

Chemical Structure : ZLN-005

CAS No.: 49671-76-3

ZLN-005 (ZLN 005;ZLN005)

Catalog No.: PC-45338Not For Human Use, Lab Use Only.

A novel small molecule PGC-1α transcriptional activator.

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Biological Activity

A novel small molecule PGC-1α transcriptional activator; increases expression of the PGC-1α gene and downstream genes by activation of AMP-activated protein kinase, and improves glucose uptake and fatty acid oxidation without obvious cytotoxicity in L6 myotubes; produces antihyperglycemia and antihyperlipidemia effects and increases insulin sensitivity in db/db mice.

Diabetes

Preclinical

Physicochemical Properties

M.Wt 250.3382
Formula C17H18N2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 47 mg/mL

Chemical Name/SMILES

1H-Benzimidazole, 2-[4-(1,1-dimethylethyl)phenyl]-

References

1. Zhang LN, et al. Diabetes. 2013 Apr;62(4):1297-307.

2. Kadlec AO, et al. Hypertension. 2017 Jul;70(1):166-173.

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