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ZLc002

Chemical Structure : ZLc002

CAS No.: 308277-46-5

ZLc002 (ZLc-002;ZLc 002)

Catalog No.: PC-35678Not For Human Use, Lab Use Only.

ZLc002 (ZLc-002) is a putative small-molecule inhibitor of nNOS interaction with NOS1AP, disrupts neuronal nitric oxide synthase-NOS1AP interaction in intact cells.

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Biological Activity

ZLc002 (ZLc-002) is a putative small-molecule inhibitor of nNOS interaction with NOS1AP, disrupts neuronal nitric oxide synthase-NOS1AP interaction in intact cells.
ZLc002 exhibits anxiolytic-like efficacy in a mouse model of chronic mild stress without altering appetite, general activity, or locomotor activity or interfering with the resting potential of neurons.
ZLc002 also inhibits co-immunoprecipitation of NOS1AP with nNOS in hippocampal cells.
ZLc002 suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability.
ZLc002 suppresses formalin-evoked inflammatory pain in rats and reduced Fos protein-like immunoreactivity in the lumbar spinal dorsal horn (4-10 mg/kg i.p.).

Physicochemical Properties

M.Wt 231.248
Formula C10H17NO5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

methyl (3-methoxy-3-oxopropanoyl)valinate

References

1. Lee WH, et al. Mol Pain. 2018 Jan-Dec;14:1744806918801224.

2. Zhu LJ, et al. Nat Med. 2014 Sep;20(9):1050-4.

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