Chemical Structure : ZN-c5
CAS No.:
2136606-87-4
ZN-c5
Catalog No.: PC-28732Not For Human Use, Lab Use Only.
ZN-c5 is a selective, brain penetrant, orally active estrogen receptor (ER) degrader (SERD) with cellular IC50 of 0.3 nM (MCF-7), binds with high affinity to ERα and ERβ (IC50=0.4 nM and 0.8 nM, respectively).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ZN-c5 is a selective, brain penetrant, orally active estrogen receptor (ER) degrader (SERD) with cellular IC50 of 0.3 nM (MCF-7), binds with high affinity to ERα and ERβ (IC50=0.4 nM and 0.8 nM, respectively).
ZN-c5 shows excellent cell potency in breast cancer lines and displayed highly favorable in vitro ADME properties across multiple species.
ZN-c5 shows excellent efficacy in multiple brain metastasis breast cancer mouse models.
Physicochemical Properties
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M.Wt
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434.49
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Formula
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C26H24F2N2O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-3-(4-((1R,3R)-2-(bicyclo[1.1.1]pentan-1-yl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-3,5-difluorophenyl)acrylic acid
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References
1. Zhang G, et al. J Med Chem. 2025 Jun 12;68(11):11990-12003.
2. Hegde SG, et al. J Med Chem. 2025 Jul 24;68(14):14740-14755.
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