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ZTA-261

Chemical Structure : ZTA-261

CAS No.: 3049368-51-3

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ZTA-261 (ZTA261)

Catalog No.: PC-24488Not For Human Use, Lab Use Only.

ZTA-261 is a thyroid hormone analog and selective agonist agonist of thyroid hormone receptor beta-subtype (TRβ, THRβ) with IC50 of 6.3 nM, >100-fold selective over TRα.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ZTA-261 is a thyroid hormone analog and selective agonist agonist of thyroid hormone receptor beta-subtype (TRβ, THRβ) with IC50 of 6.3 nM, >100-fold selective over TRα.
ZTA-261 is more selective towards THRβ than GC-1. effective as GC-1 in reducing the levels of serum and liver lipids.
ZTA-261 significantly increased Dio1 and Me1 expression, also upregulated Thrsp.
ZTA-261 at 1 µmol/kg·day reduced fat droplets to a level comparable to that in animals fed a normal diet.

Physicochemical Properties

M.Wt 428.33
Formula C21H14F6O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzeneacetic acid, 4-[(4-hydroxy-1-naphthalenyl)methyl]-3,5-bis(trifluoromethyl)-

References

1. Nambo M, et al. Commun Med (Lond). 2024 Aug 6;4(1):152.

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