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Chemical Structure : ZYTP1
Catalog No.: PC-35506Not For Human Use, Lab Use Only.
ZYTP1 is a novel, oral PARP inhibitor that inhibits PARP1, PARP2, Tankyrase-1 and Tankyrase-2 with IC50 of 5.4, 0.7, 133.3 and 289.8 nM, respectively.
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ZYTP1 is a potent, oral PARP inhibitor that inhibits PARP1, PARP2, Tankyrase-1 and Tankyrase-2 with IC50 of 5.4, 0.7, 133.3 and 289.8 nM, respectively.
ZYTP1 potentiates MMS mediated cell killing of cancer cells in vitro (SW620 PF50=6.4).
ZYTP1 displays potent antitumor activity in BRCA-deficient models and potentiated the activity of other conventional chemotherapeutic drugs.
| M.Wt | 431.471 | |
| Formula | C24H22FN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jain MR, et al. Cancer Chemother Pharmacol. 2018 Jul 25. doi: 10.1007/s00280-018-3653-1.
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