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Chemical Structure : Zandelisib
CAS No.: 1401436-95-0
Catalog No.: PC-20568Not For Human Use, Lab Use Only.
Zandelisib (ME-401, PWT-143) is a potent, selective and orally active inhibitor of phosphatidylinositol 3 kinase p110δ with IC50 of 3.5 nM.
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|---|---|---|---|
| 5 mg | $228 | In stock | |
| 25 mg | $498 | In stock | |
| 50 mg | $758 | In stock | |
| 100 mg | $1280 | In stock | |
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Zandelisib (ME-401, PWT-143) is a potent, selective and orally active inhibitor of phosphatidylinositol 3 kinase p110δ with IC50 of 3.5 nM.
Zandelisib inhibits PI3Ks with IC50s of 4, 976 nM, 605 nM, 817 nM and 3.5 nM for p110α, p110β, p110γ and p110δ, respectivey.
| M.Wt | 576.68 | |
| Formula | C31H38F2N8O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
CN1CCC(C2=CC=CC=C2CC(NC3=NC(N4C5=CC=CC=C5N=C4C(F)F)=NC(N6CCOCC6)=N3)(C)C)CC1 |
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1. Moreno O, et al. Clin Ther. 2018 Nov;40(11):1855-1867.
2. Patent WO2019183226A1.
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