Chemical Structure : Zardaverine
CAS No.: 101975-10-4
Catalog No.: PC-25667Not For Human Use, Lab Use Only.
Zardaverinea is a potent, specific PDE III/IV (PDE3/4) inhibitor, inhibits PDE III from human platelets and the rolipram-inhibitable PDE IV from canine trachea and human polymorphonuclear (PMN) cells with IC50 of 0.58, 0.79 and 0.17uM, respectively.
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Zardaverinea is a potent, specific PDE III/IV (PDE3/4) inhibitor, inhibits PDE III from human platelets and the rolipram-inhibitable PDE IV from canine trachea and human polymorphonuclear (PMN) cells with IC50 of 0.58, 0.79 and 0.17uM, respectively.
Zardaverine inhibits the ADP-induced aggregation of human platelets with an IC50 of 1.6 uM.
Zardaverine inhibits the zymosan-induced superoxide anion generation with IC50 of 0.4 uM in human PMN cells.
| M.Wt | 268.22 | |
| Formula | C12H10F2N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-(4-(Difluoromethoxy)-3-methoxyphenyl)pyridazin-3(2H)-one |
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1. Schudt C, et al. Agents Actions Suppl. 1991;34:379-402.
2. Schudt C, et al. Biochem Pharmacol. 1991 Jun 21;42(1):153-62.

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