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Zardaverine

Chemical Structure : Zardaverine

CAS No.: 101975-10-4

Zardaverine

Catalog No.: PC-25667Not For Human Use, Lab Use Only.

Zardaverinea is a potent, specific PDE III/IV (PDE3/4) inhibitor, inhibits PDE III from human platelets and the rolipram-inhibitable PDE IV from canine trachea and human polymorphonuclear (PMN) cells with IC50 of 0.58, 0.79 and 0.17uM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Zardaverinea is a potent, specific PDE III/IV (PDE3/4) inhibitor, inhibits PDE III from human platelets and the rolipram-inhibitable PDE IV from canine trachea and human polymorphonuclear (PMN) cells with IC50 of 0.58, 0.79 and 0.17uM, respectively.
Zardaverine inhibits the ADP-induced aggregation of human platelets with an IC50 of 1.6 uM.
Zardaverine inhibits the zymosan-induced superoxide anion generation with IC50 of 0.4 uM in human PMN cells.

Physicochemical Properties

M.Wt 268.22
Formula C12H10F2N2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

6-(4-(Difluoromethoxy)-3-methoxyphenyl)pyridazin-3(2H)-one

References

1. Schudt C, et al. Agents Actions Suppl. 1991;34:379-402.

2. Schudt C, et al. Biochem Pharmacol. 1991 Jun 21;42(1):153-62.

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