Catalog No.: PC-38430Not For Human Use, Lab Use Only.
Zastaprazan (JP-1366) is a potent selective inhibitor of gastric H+/K+-ATPase activity with IC50 of 16.7 nM, >400-fold selectivity over Na+/K+-ATPase activity.
Zastaprazan (JP-1366) is a potent selective inhibitor of gastric H+/K+-ATPase activity with IC50 of 16.7 nM, >400-fold selectivity over Na+/K+-ATPase activity.
JP-1366 (2 mg/kg) inhibits basal and histamine-stimulated gastric acid secretion in pylorus-ligated rats.
JP-1366 inhibits esophageal mucosal damage in a reflux esophagitis model with ED50 of 0.53 mg/kg.
JP-1366 exhibits a more than 2-fold higher inhibitory effect on esophageal injury than TAK-438 in GERD lesions and has a more potent inhibitory effect in indomethacin- or aspirin-induced gastric ulcer rat models than TAK-438.
