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Zastaprazan

Chemical Structure : Zastaprazan

CAS No.: 2133852-18-1

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Zastaprazan (JP-1366, JP1366)

Catalog No.: PC-38430Not For Human Use, Lab Use Only.

Zastaprazan (JP-1366) is a potent selective inhibitor of gastric H+/K+-ATPase activity with IC50 of 16.7 nM, >400-fold selectivity over Na+/K+-ATPase activity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Zastaprazan (JP-1366) is a potent selective inhibitor of gastric H+/K+-ATPase activity with IC50 of 16.7 nM, >400-fold selectivity over Na+/K+-ATPase activity.
    JP-1366 (2 mg/kg) inhibits basal and histamine-stimulated gastric acid secretion in pylorus-ligated rats.
    JP-1366 inhibits esophageal mucosal damage in a reflux esophagitis model with ED50 of 0.53 mg/kg.
    JP-1366 exhibits a more than 2-fold higher inhibitory effect on esophageal injury than TAK-438 in GERD lesions and has a more potent inhibitory effect in indomethacin- or aspirin-induced gastric ulcer rat models than TAK-438.

    Physicochemical Properties

    M.Wt 362.477
    Formula C22H26N4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    azetidin-1-yl(8-((2,6-dimethylbenzyl)amino)-2,3-dimethylimidazo[1,2-a]pyridin-6-yl)methanone

    References

    1. Jin Mo Ku, et al. Pharmacol Res Perspect. 2023 Jun;11(3):e01090.

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