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Zatebradine hydrochloride

Chemical Structure Zatebradine hydrochloride

CAS No.: 91940-87-3

Zatebradine hydrochloride (UL-FS-49;UL-FS-49CL)

Catalog No.: PC-43526Not For Human Use, Lab Use Only.

Zatebradine hydrochloride (UL-FS49) is a potent blocker (antagonist) of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel, a specific bradycardic agent.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Zatebradine hydrochloride (UL-FS49) is a potent blocker (antagonist) of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel, a specific bradycardic agent; blocks cardiac pacemaker current (If), decreases the rate of spontaneously beating guinea-pig atria with EC50 of 0.030 ug/mL.

Heart Failure

Discontinued

Physicochemical Properties

M.Wt 493.0354
Formula C26H37ClN2O5
CAS No. 91940-87-3
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
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Solubility

10 mM in DMSO

Chemical Name

2H-3-Benzazepin-2-one, 3-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-, hydrochloride (1:1)

Clinical Information

References

1. Van Bogaert PP, et al. Eur J Pharmacol. 2003 Oct 8;478(2-3):161-71.

2. McGovern AE, et al. Br J Pharmacol. 2014 Aug;171(15):3633-50.

3. Gill CH, et al. Br J Pharmacol. 2004 Oct;143(3):411-21.

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