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Chemical Structure : Zenuzolac
CAS No.: 6501-72-0 (racemate)
Catalog No.: PC-38433Not For Human Use, Lab Use Only.
Zenuzolac (GLS1027, VGX-1027) is a small molecule immunosuppressant and an orally available isoxazole compound, inhibits toll-like receptor 4 (TLR4) activity, has shown promise for the treatment of several neuroinflammatory disorders.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 100 mg | $458 | In stock | |
| 250 mg | $858 | In stock | |
| 1 g | Get quote |
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Zenuzolac (GLS1027, VGX-1027) is a small molecule immunosuppressant and an orally available isoxazole compound, inhibits toll-like receptor 4 (TLR4) activity, has shown promise for the treatment of several neuroinflammatory disorders.
VGX-1027 modulates genes involved in lipopolysaccharide-induced Toll-like receptor 4 activation and in a murine model of systemic lupus erythematosus.
VGX-1027 attenuates self-grooming and marble burying behaviors, and enhance social interactions in BTBR mice, VGX-1027 treatment resulted in a substantial decrease in IL-1β, IL-6, TNF-α, IFN-γ, and NF-κB p65 production, but increased IL-10 production in CD4+ T cells.
| M.Wt | 205.213 | |
| Formula | C11H11NO3 | |
| Appearance | Solid | |
| Storage |
|
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(R)-2-(3-phenyl-4,5-dihydroisoxazol-5-yl)acetic acid |
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1. Mangano K, et al. Br J Pharmacol. 2008 Nov;155(5):722-30.
2. Fagone P, et al. Immunology. 2014 Aug;142(4):594-602.
3. Laird MD, et al. Glia. 2014 Jan;62(1):26-38.
4. Sheikh F Ahmad, et al. Life Sci. 2019 Nov 15;237:116930.
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