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Chemical Structure : Zimberelimab
Catalog No.: PC-38874Not For Human Use, Lab Use Only.
GLS-010 (Zimberelimab, AB122) is a fully human, monoclonal immunoglobulin G4 (IgG4) anti-programmed death-1 (PD-1) antibody that shows promising efficacy and safety in advanced solid tumors.
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GLS-010 (Zimberelimab, AB122) is a fully human, monoclonal immunoglobulin G4 (IgG4) anti-programmed death-1 (PD-1) antibody that shows promising efficacy and safety in advanced solid tumors.
GLS-010 (Zimberelimab) has a high affinity to PD-1 with dissociation constant (KD) of 0.175 nM.
GLS-010 (Zimberelimab) could effectively block the binding of PD-L1/2 to PD-1.
GLS-010 (Zimberelimab) showed statistically significant anti-tumor effects in the MC38 model in human PD-1 knock-in mice.
Isotype: IgG4-lambda.
Anti-[human PDCD1 (programmed cell death 1, PD-1, PD1, CD279)], human monoclonal antibody.
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| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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