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Zolbetuximab

Chemical Structure : Zolbetuximab

CAS No.:

Zolbetuximab (Anti-human Claudin 18.2 mAb, human IgG1-Kappa)

Catalog No.: PC-Ab1015Not For Human Use, Lab Use Only.

Zolbetuximab is a first-in-class chimeric IgG1 mAb that specifically binds to Claudin 18 splice variant 2 (CLDN18.2) on the cell surface and mediates cell death through antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity. Claudin-18 (CLDN18) is a highly specific TJ component of the stomach. It is expressed in foetal and in adult normal gastric mucosa.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Zolbetuximab is a first-in-class chimeric IgG1 mAb that specifically binds to Claudin 18 splice variant 2 (CLDN18.2) on the cell surface and mediates cell death through antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity. Claudin-18 (CLDN18) is a highly specific TJ component of the stomach. It is expressed in foetal and in adult normal gastric mucosa

Physicochemical Properties

M.Wt
Formula Human IgG1-Kappa
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives

Chemical Name/SMILES

References

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