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Chemical Structure : Zotarolimus
CAS No.: 221877-54-9
Catalog No.: PC-43029Not For Human Use, Lab Use Only.
Zotarolimus (ABT-578, A 179578) is a semi-synthetic analogue of rapamycin, inhibits FKBP-12 binding with IC50 of 2.8 nM and shows less potent systemic immunosuppression than rapamycin.
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| 10 mg | $198 | In stock | |
| 25 mg | $318 | In stock | |
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Zotarolimus (ABT-578, A 179578) is a semi-synthetic analogue of rapamycin, inhibits FKBP-12 binding with IC50 of 2.8 nM and shows less potent systemic immunosuppression than rapamycin.
Zotarolimus (ABT-578, A 179578) effectively inhibits both smooth muscle cell and endothelial cell proliferation, with IC50 values of 2.9 nM and 2.6 nM, respectively.
Zotarolimus (ABT-578, A 179578) exhibits high-affinity binding to the immunophilin FKBP12, inhibiting in vitro proliferation of both human and rat T cells.
Zotarolimus (ABT-578, A 179578) inhibits Con A-induced human T cells with IC50 of 7.0 nM.
Zotarolimus (ABT-578, A 179578) reduces early complications and improve late clinical outcomes in patients needing interventional cardiology.
| M.Wt | 966.21 | |
| Formula | C52H79N5O12 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 33 mg/mL |
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| Chemical Name/SMILES |
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)- |
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1. Garcia-Touchard A, et al. Eur Heart J. 2006 Apr;27(8):988-93.
2. Chen YW, et al. J Cardiovasc Pharmacol. 2007 Apr;49(4):228-35.
3. Abizaid A, et al. Am J Cardiol. 2007 May 15;99(10):1403-8.
4. Wagner R, et al. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5340-3.
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