Catalog No.: PC-62443Not For Human Use, Lab Use Only.
Bisperoxovanadium (bpV(phen) potassium hydrate) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 =38 nM), also inhibits the vascular endothelial PTP, PTP-β (IC50=343 nM), and PTP-1β (IC50=920 nM).
Bisperoxovanadium (bpV(phen) potassium hydrate) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 =38 nM), also inhibits the vascular endothelial PTP, PTP-β (IC50=343 nM), and PTP-1β (IC50=920 nM).
Bisperoxovanadium activates the insulin receptor tyrosine kinase and promotes downstream signaling, including activation of PI3-kinase.
Physicochemical Properties
M.Wt
404.3
Formula
C12H8N2O5V • K+(H2O)3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
References
1. Castaldi L, et al. FASEB J. 2007 Nov;21(13):3573-83.
2. Paliwal P, et al. Chem Biol. 2011 Sep 23;18(9):1153-66.
3. Lai JP, et al. Br J Pharmacol. 2007 Dec;152(8):1172-84.
