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Chemical Structure : cGAS inhibitor 3
Catalog No.: PC-49403Not For Human Use, Lab Use Only.
cGAS inhibitor 3 is a potent, selective and covalent inhibitor of cyclic GMP-AMP synthase (cGAS) with cellular IC50 of 0.51 uM.
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cGAS inhibitor 3 is a potent, selective and covalent inhibitor of cyclic GMP-AMP synthase (cGAS) with cellular IC50 of 0.51 uM.
cGAS inhibitor 3 directly and covalently binds to Cys419 of cGAS.
cGAS inhibitor 3 displayed high potency and selectivity at the cellular level.
cGAS inhibitor 3 demonstrated promising therapeutic efficacy in a dextran sulfate sodium (DSS)-induced mouse colitis model.
cGAS inhibitor 3 exhibited better inhibitory activity and pathway selectivity than RU.521, which is a selective cGAS inhibitor with anti-inflammatory effects in vitro and in vivo.
| M.Wt | 250.301 | |
| Formula | C16H14N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jia Song, et al. Acta Pharmacol Sin. 2022 Oct 13. doi: 10.1038/s41401-022-01002-5.
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