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Chemical Structure : cIAP1 E3 ligase inhibitor D19-14
Catalog No.: PC-35676Not For Human Use, Lab Use Only.
cIAP1 E3 ligase inhibitor D19-14 (cIAP1 inhibitor D19-14) is an improved analog of D19, demonstrates significantly increased ability to inhibit cIAP1 autoubiquitination and reduce protein levels of c-MYC in vitro.
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cIAP1 E3 ligase inhibitor D19-14 (cIAP1 inhibitor D19-14) is an improved analog of D19, demonstrates significantly increased ability to inhibit cIAP1 autoubiquitination and reduce protein levels of c-MYC in vitro; D19-14 is more potent in inhibiting the proliferation of cancer cells than D19, D19-14 exhibits acceptable pharmacokinetics properties in vivo, effectively decreases the levels of c-MYC protein in tumors in cancer xenograft model.
| M.Wt | 385.456 | |
| Formula | C18H15N3O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Li H, et al. Proc Natl Acad Sci U S A. 2018 Sep 4. pii: 201807711.
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