Catalog No.: PC-25167Not For Human Use, Lab Use Only.
class I HDACs inhibitor JT86 is a potent class I HDACs inhibitor with IC50 of 0.72/8.0/2.0 nM for HDAC1/2/3 respectively, 61-fold selectivity over HDAC8 (IC50 44 nM) and 11-fold over HDAC2.
class I HDACs inhibitor JT86 is a potent class I HDACs inhibitor with IC50 of 0.72/8.0/2.0 nM for HDAC1/2/3 respectively, 61-fold selectivity over HDAC8 (IC50 44 nM) and 11-fold over HDAC2.
JT86 is much less active against the class IIa enzyme HDAC7.
JT86 shows potent cytotoxic effect (IC50= 0.02-0.1 μM) across the five cancer cell lines with 15- to 23-fold increased potency over AR-42.
JT86 induces concentration-dependent accumulation of acetylated histone H4 in MM96L melanoma cells, indicating inhibition of endogenous HDAC1.
