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Chemical Structure : cyclo-CRVLIR
Catalog No.: PC-20008Not For Human Use, Lab Use Only.
cyclo-CRVLIR is a cyclic peptide that binds selectively to p110α RAS binding domain (p110α-RBD) with ITC Kd of 3 uM, blocks p110α/RAS interaction in vitro and KRAS cancer cell lines.
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cyclo-CRVLIR is a cyclic peptide that binds selectively to p110α RAS binding domain (p110α-RBD) with ITC Kd of 3 uM, blocks p110α/RAS interaction in vitro and KRAS cancer cell lines.
cyclo-CRVLIR is specific for the RBD of p110α and not the other PI3K isoforms, and shows no affinity to KRAS or the structurally-related RAF-RBD.
cyclo-CRVLIR blocks p110α/KRAS interaction using MST assays with Kd of 4.4 uM.
Cyclo-CRVLIR (2, 10 and 50 µM) inhibits AKT phosphorylation (pAKT-Ser473) in human lung cancer cell line H1792.
| M.Wt | 728.96 | |
| Formula | C31H60N12O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ismail M, et al. Sci Rep. 2023 Feb 2;13(1):1889.
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