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dCeMM2

Chemical Structure : dCeMM2

CAS No.: 296771-07-8

dCeMM2

Catalog No.: PC-21962Not For Human Use, Lab Use Only.

dCeMM2 is a small glue degrader, induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

dCeMM2 is a small glue degrader, induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex.

Physicochemical Properties

M.Wt 370.82
Formula C16H11ClN6OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-((5H-[1,2,4]Triazino[5,6-b]indol-3-yl)thio)-N-(5-chloropyridin-2-yl)acetamide

References

1. Mayor-Ruiz C, et al. Nat Chem Biol. 2020;16(11):1199-1207.

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