diBSP01

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Chemical Structure : diBSP01

Catalog No.: PC-26987Not For Human Use, Lab Use Only.

diBSP01 is a potent dimer agonist of STING, exhibits promising binding properties (ITC KD=218 nM, hSTINGH232 protein) and agonistic potency in vitro.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

diBSP01 is a potent dimer agonist of STING, exhibits promising binding properties (ITC KD=218 nM, hSTINGH232 protein) and agonistic potency in vitro.
diBSP01 also shows strong affinity towards hSTINGR232 and hSTINGHAQ protein.
diBSP01 reliably targets the STING adaptor in the cGAS-STING pathway.
diBSP01 significantly induces the expression of downstream genes including IL6, CXCL10, and IFNβ in THP1 cells and shows a more potent STING activation ability than MSA-2 (Cat# PC-73371).

Physicochemical Properties

M.Wt	694.45
Formula	C29H28O10Se2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4,4'-((propane-1,3-diylbis(oxy))bis(6-methoxybenzo[b]selenophene-5,2-diyl))bis(4-oxobutanoic acid)

References

1. Liu D, et al. Chem Sci. 2023 Mar 13;14(15):4174-4182.

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diBSP01

Biological Activity

Physicochemical Properties

References

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