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Chemical Structure : iCDK9
CAS No.: 1263369-28-3
Catalog No.: PC-35631Not For Human Use, Lab Use Only.
iCDK9 (i-CDK9) is a potent, highly selective CDK9 inhibitor (IC50<0.4 nM, CDK9-CycT1 kinase), exhibits >600-fold selectivity toward CDK1-CycB, CDK2-CycA, CDK4-CycD1, CDK7-CycH-MAT1 and CDK8-CycC.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $588 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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iCDK9 (i-CDK9, CDK9-IN-2) is a potent, highly selective CDK9 inhibitor (IC50<0.4 nM, CDK9-CycT1 kinase), exhibits >600-fold selectivity toward CDK1-CycB, CDK2-CycA, CDK4-CycD1, CDK7-CycH-MAT1 and CDK8-CycC.
iCDK9 potently suppresses CDK9 phosphorylation of substrates and causes genome-wide Pol II pausing.
iCDK9 efficiently suppresses P-TEFb's phosphorylation of the Pol II CTD and the DSIF subunit SPT5 and causes widespread Pol II pausing at gene promoters, enhances the MYC mRNA production but not protein stability.
| M.Wt | 425.936 | |
| Formula | C23H25ClFN5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N2'-((1r,4r)-4-aminocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diamine |
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1. Lu H, et al. Elife. 2015 Jun 17;4:e06535. doi: 10.7554/eLife.06535.
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