You are here:Home-Chemical Inhibitors & Agonists-Antibiotics and Antivirals-Bacterial-mCLB073
mCLB073

Chemical Structure : mCLB073

CAS No.:

mCLB073 (mCLB 073)

Catalog No.: PC-72874Not For Human Use, Lab Use Only.

mCLB073 (mCLB 073) is a more potent, specific, oral small molecule agonist of the Mtb adenylyl cyclase Rv1625c, an optimized analog of the V-59 for in vivo use.

Packing Price Stock Quantity
25 mg Get quote
100 mg Get quote
250 mg Get quote
1 g Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC)

Biological Activity

mCLB073 (mCLB 073) is a more potent, specific, oral small molecule agonist of the Mtb adenylyl cyclase Rv1625c, an optimized analog of the V-59 for in vivo use.
mCLB073 exhibited 17-fold potency improvement against Mtb in cholesterol media relative to V-59 while maintaining excellent pharmacokinetic properties and a good safety profile.
mCLB073 (30 mg/kg, oral) reduced Mtb CFUs in the lungs of mice significantly and decreased the extent of lung pathology by 45%.

Physicochemical Properties

M.Wt 421.282
Formula C18H18Cl2N6O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Month
Shipping
Solubility

Chemical Name/SMILES

References

1. Kaley M Wilburn, et al. PLoS Pathog. 2022 Feb 8;18(2):e1009862.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: