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Chemical Structure : mTOR inhibitor 10
Catalog No.: PC-60920Not For Human Use, Lab Use Only.
A novel potent, selective mTOR inhibitor with biochemical IC50 of 21.7 nM for mTORC1, exhibits cellular potency against mTOR with IC50 of 5 nM.
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A novel potent, selective mTOR inhibitor with biochemical IC50 of 21.7 nM for mTORC1, exhibits cellular potency against mTOR with IC50 of 5 nM; displays >50-fold selectivity over PIKKs (hVSP34, PI3Ks, PI4K, etc.); exhibits significant inhibitory activity against the downstream targets of mTOR, S6K, and Akt, and blocks 80-90% phosphorylation of S6K (T389) and pAkt (S473) in liver and lung tissues, along with significantly improved mouse liver microsome stability and a longer in vivo half-life.
| M.Wt | 683.735 | |
| Formula | C41H32F3N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Liu Q, et al. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4036-40.
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