nNOS-PDZ inhibitor N24

Chemical Structure : nNOS-PDZ inhibitor N24

Catalog No.: PC-27032Not For Human Use, Lab Use Only.

nNOS-PDZ inhibitor N24 is a potent and selective small-molecule inhibitor of PDZ domain of neuronal nitric oxide synthase (nNOS-PDZ) with IC50 of 0.76 uM in FP assays.

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Biological Activity

nNOS-PDZ inhibitor N24 is a potent and selective small-molecule inhibitor of PDZ domain of neuronal nitric oxide synthase (nNOS-PDZ) with IC50 of 0.76 uM in FP assays.
N24 produces rapid, dose-dependent antidepressant effects in mouse models of depression induced by chronic unpredictable mild stress (CUMS) and chronic corticosterone treatment.

Physicochemical Properties

M.Wt	322.33
Formula	C16H12F2O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	8-fluoro-6-(2-fluoro-4-methylbenzyl)benzo[e][1,2]oxathiine 2,2-dioxide

References

1. Liting Zhang, et al. J Med Chem. 2026 Jun 3. doi: 10.1021/acs.jmedchem.6c00391.

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