nor-Binaltorphimine dihydrochloride

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Chemical Structure : nor-Binaltorphimine dihydrochloride

CAS No.: 113158-34-2

Catalog No.: PC-27173Not For Human Use, Lab Use Only.

nor-Binaltorphimine dihydrochloride (Nor-BNI, Norbinaltorphimine) is a potent, selective, long-acting competitive κ-opioid receptor (KOR) antagonist, blocks KOR-mediated analgesic effects, and inhibits butorphanol-induced changes in κ-opioid receptor binding kinetics, desensitization and down-regulation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Physicochemical Properties

M.Wt	734.71
Formula	C40H43N3O6.2ClH
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(4bS,8R,8aS,10aS,11R,14aS,19aR,20bR)-7,12-bis(cyclopropylmethyl)-5,6,7,8,9,10,11,12,13,14,19a,20b-dodecahydro-20H-4,8:11,15-dimethanobis(benzofuro)[2,3-a:3',2'-i]dipyrido[4,3-b:3',4'-h]carbazole-1,8a,10a,18-tetraol dihydrochloride

References

1. Spanagel R, et al. Eur J Pharmacol. 1994;264(2):157-162.

2. Jaw SP, et al. Eur J Pharmacol. 1993;239(1-3):133-140.

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