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Chemical Structure : proTAME
Catalog No.: PC-63040Not For Human Use, Lab Use Only.
proTAME is a cell permeable prodrug of TAME, which is an anaphase-promoting complex/cyclosome (APC/C) inhibitor that binds to the APC preferentially suppresses APC/C(Cdc20).
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proTAME is a cell permeable prodrug of TAME, which is an anaphase-promoting complex/cyclosome (APC/C) inhibitor that binds to the APC preferentially suppresses APC/C(Cdc20); arrests cells in metaphase without perturbing the spindle, but is dependent on the spindle assembly checkpoint (SAC); efficiently targets osteosarcoma in vitro combined with chemotherapeutic agents.
| M.Wt | 726.8 | |
| Formula | C34H38N4O12S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zeng X, et al. Cancer Cell. 2010 Oct 19;18(4):382-95.
2. Giovinazzi S, et al. Cell Cycle. 2013 Aug 15;12(16):2598-607.
3. Hu K, et al. Oncotarget. 2014 May 30;5(10):3088-100.
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