Catalog No.: PC-44374Not For Human Use, Lab Use Only.
rac-Rotigotine hydrochloride is a non-selective agonist of the dopamine D3 receptor (Ki=0.71 nM), has 10-fold selectivity for the D3 receptor over the D2, D4, and D5 receptors and 100-fold selectivity for the D3 receptor over the D1 receptor.
rac-Rotigotine hydrochloride is a non-selective agonist of the dopamine D3 receptor (Ki=0.71 nM), has 10-fold selectivity for the D3 receptor over the D2, D4, and D5 receptors and 100-fold selectivity for the D3 receptor over the D1 receptor.
rac-Rotigotine hydrochloride behaves as a full agonist of D1, D2, and D3 with similar potencies (EC50) in functional assay.
rac-Rotigotine hydrochloride also demonstrates significant affinity at α-adrenergic (α2B, Ki=27 nM) and serotonin receptors (5-HT1A Ki=30 nM).
rac-Rotigotine hydrochloride significantly attenuates MPTP-induced acute cell degeneration in mouse model.
