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Chemical Structure : sPLA2-X inhibitor 31
Catalog No.: PC-35307Not For Human Use, Lab Use Only.
sPLA2-X inhibitor 31 is a potent, selective secreted phospholipase A2 type X (sPLA2-X) with IC50 of 26 nM, displays 12-fold and 80-fold selectivity over sPLA2-Iia and sPLA2-V, respectively.
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sPLA2-X inhibitor 31 is a potent, selective secreted phospholipase A2 type X (sPLA2-X) with IC50 of 26 nM, displays 12-fold and 80-fold selectivity over sPLA2-Iia and sPLA2-V, respectively.
sPLA2-X inhibitor 31 demonstrates improved lipolitic activity of sPLA2-X on HDL (IC50=270 nM), does not display any significant binding to a large panel of biological targets and no significant inhibition of ion channels, enzymes and transporters that might be related to toxicity
| M.Wt | 392.334 | |
| Formula | C19H15F3N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Knerr L, et al. ACS Med Chem Lett. 2018 Jun 23;9(7):594-599.
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