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Chemical Structure : slCeMM1
Catalog No.: PC-20896Not For Human Use, Lab Use Only.
slCeMM1 is a potent, highly selective inhibitor of lactate transporter SLC16A3 (MCT4), inhibits intracellular lactate accumulation in SLC16A3 dependent cells (IC50=91 nM).
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slCeMM1 is a potent, highly selective inhibitor of lactate transporter SLC16A3 (MCT4), inhibits intracellular lactate accumulation in SLC16A3 dependent cells (IC50=91 nM).
slCeMM1 displays no effec on intracellular lactate accumulationt in cells dependent on SLC16A1.
slCeMM1 inhibits growth of HAP1 cells dependent on SLC16A3 (IC50 = 0.88 μM), but not on SLC16A1, SLC16A7 or SLC16A8, and this effect was rescued by re-introduction of SLC16A1WT but not transport-deficient mutant SLC16A1R313Q.
slCeMM1 is a valuable additional tool that helps to chemically validate SLC16A3 as a target based on experiments with gene knock-out/knock-down strategies.
| M.Wt | 414.39 | |
| Formula | C20H17F3N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dvorak V, et al. Cell Chem Biol. 2023 Jul 15:S2451-9456(23)00204-0.
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