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Chemical Structure : tatM2NX
Catalog No.: PC-72122Not For Human Use, Lab Use Only.
tatM2NX is a novel potent, selective, cell permeable, peptide TRPM2 channel antagonist with IC50 of 396 nM, IC90 of 2 uM (TRPM2 channel currents), prevents ligand binding and TRPM2 activation.
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tatM2NX is a novel potent, selective, cell permeable, peptide TRPM2 channel antagonist with IC50 of 396 nM, IC90 of 2 uM (TRPM2 channel currents), prevents ligand binding and TRPM2 activation.
tatM2NX interacts with the ADPR binding site on the NUT9-H domain of TRPM2 channel. tatM2NX inhibits TRPM2-mediated dephosphorylation of GSK3β (activation), tatM2NX demonstrated selective neuroprotective effects in a mouse model of focal ischemia (stroke).
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1. Cruz-Torres I, et al. Mol Pharmacol. 2020 Feb;97(2):102-111.
2. Dietz RM, et al. Transl Stroke Res. 2020 Apr;11(2):254-266.
3. Dietz RM, et al. Neural Plast. 2021 Oct 6;2021:8774663.
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