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Chemical Structure : β-catenin inhibitor C2
Catalog No.: PC-72072Not For Human Use, Lab Use Only.
β-catenin inhibitor C2 is a novel potent selective β-catenin inhibitor with Kd of 54.96 nM, directly to ARM domain of β-catenin.
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β-catenin inhibitor C2 is a novel potent selective β-catenin inhibitor with Kd of 54.96 nM, directly to ARM domain of β-catenin.
β-catenin inhibitor C2 reduced viability of DLD1 and SW480 cells in dose-dependent manner with IC50 ranging between 0.8-1.3 uM, viability of HCT116 and SW48 with IC50 3.45-5.35 uM.
β-catenin inhibitor C2 selectively inhibits β-catenin, lowers its cellular load and significantly reduces viability of β-catenin-driven cancer cells.
| M.Wt | 484.25 | |
| Formula | C19H20Br2N2OS | |
| Appearance | Solid | |
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1. Anton Cheltsov, et al. Sci Rep. 2020 May 15;10(1):8096.
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