Catalog No.: PC-35337Not For Human Use, Lab Use Only.
ζ-Stat (1,3,6-Naphthalenetrisulfonic acid) is a novel PKC-zeta (PKC-ζ) specific inhibitor with IC50 of 5 uM, shows only 13% inhibition on PKC-I at 20 uM.
ζ-Stat (1,3,6-Naphthalenetrisulfonic acid) is a novel PKC-zeta (PKC-ζ) specific inhibitor with IC50 of 5 uM, shows only 13% inhibition on PKC-I at 20 uM.
ζ-Stat downregulates TNF-α induced NF-κB translocation to the nucleus there by inducing apoptosis.
ζ-Stat significantly decreases melanoma cell proliferation of SK-MEL-2 and MeWo.
Physicochemical Properties
M.Wt
384.344
Formula
C10H8O10S3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
8-hydroxy-1,3,6-naphthalenetrisulfonic acid
References
1. Islam SMA, et al. Biochim Biophys Acta. 2018 Apr;1865(4):650-664.
2. Ratnayake WS, et al. Cell Adh Migr. 2018 May 21:1-17.
