ATM/ATR compound (inhibitors, antagonists)-ProbeChem.com

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Cat. No.	Product Name	Information
PC-24377	WSD0628 ATM inhibitor	WSD0628 (WSD-0628) is a potent, selective, orally bioavailable and CNS penetrant ATM inhibitor, potently inhibits ATM-mediated phosphorylation of the DNA damage response protein KAP1 in MCF-7 cells with IC50 of 0.42 nM.
PC-24257	YY2201 ATR inhibitor	YY2201 is a highly potent and selective ATR inhibitor with IC50 of 8 nM, >200-fold selective over mTOR.
PC-22829	AZ20 ATR inhibitor	AZ20 is a potent and selective ATR inhibitor, inhibits ATR immunoprecipitated from HeLa nuclear extracts with IC50 of 5 nM and ATR mediated phosphorylation of Chk1 in HT29 colorectal adenocarcinoma tumor cells with IC50 of 50 nM.
PC-22114	XRD-0394 hydrochloride ATM/DNA-PK inhibitor	XRD-0394 hydrochloride (XRD0394) is a potent, specific, orally bioavailable dual inhibitor of DNA damage-response kinases ATM and DNA-PK with IC50 of 0.39 and 0.89 nM, respectively.
PC-21858	Tuvusertib ATR inhibitor	Tuvusertib (M1774) is a potent, selective, orally bioavailable ATR protein kinase inhibitor, shows anticancer activity against cance cell with expression the ATR inhibition sensitizing mixed lineage leukemia fusion protein.

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