| Cat. No. |
Product Name |
Information |
| PC-62553 |
Disarib
BCL2-BAK inhibitor
|
Disarib is a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain, demonstrates strong affinity to BCL2, but not to other antiapoptotic BCL2 family members(BCL-xL, BCL2A1 etc.). |
| PC-62551 |
Mcl-1-Puma inhibitor 8
Mcl-1-PUMA inhibitor
|
Mcl-1-Puma inhibitor 8 is a small-molecule dual-acting compound that targets the apoptotic Mcl-1-PUMA interface with Ki of 0.3 uM (Mcl-1, FPA), reduces multiple cancer cells and inhibits PUMA-mediated apoptosis. |
| PC-62538 |
BCL6-IN-8
BCL6 inhibitor
|
BCL6-IN-8 (BCL6-i) is a potent, irreversible and cell-active BCL6 inhibitor with inact/KI value of 1.9 × 104 M-1 s-1, targets Cys53 located at the protein-protein interaction interface. |
| PC-61988 |
AZD 4320
Bcl-2/Bcl-XL inhibitor
|
AZD4320 is a BH3 mimetic and dual Bcl-2/Bcl-XL inhibitor with IC50 of <1 nM. |
| PC-61404 |
AZD 5991
Mcl-1 inhibitor
|
AZD 5991 (AZD5991) is a potent and selective macrocyclic inhibitor of Mcl-1 with sub-nanomolar affinity (SPR Kd=0.17 nM). |
| PC-61318 |
(-) BI97D6
BCL-2 inhibitor
|
(-) BI97D6 (BI112D1) is a potent, pan-active inhibitor of Bcl-2 family proteins with IC50 of 76, 31, 25, and 122 nM for Bcl-xL, Bcl-2, Mcl-1, and Bfl-1, respectively. |
| PC-60951 |
BI-5273
|
BI-5273 is a negative control compound of BI-3802 and BI-3812, which are potent and efficacious BCL6 degrader and inhibitor, respectively. |
| PC-60950 |
BI-3812
BCL6 inhibitor
|
BI-3812 is a highly potent and efficacious BCL6 inhibitor that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM. |
| PC-60949 |
BI-3802
BCL6 inhibitor
|
BI-3802 (BI3802) is a highly potent and efficacious BCL6 degrader that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM. |
| PC-60941 |
DAN004
Bax inhibitor
|
DAN 004 is a small molecule Bax inhibitor that inhibits Bax/Bak oligomerization and prevents mitochondrial outer membrane permeabilization (MOMP) with IC50 of 0.7 uM. |
| PC-60940 |
MSN-125
Bax inhibitor
|
MSN-125 (MSN 125, MSN125) is a small molecule Bax inhibitor that inhibits Bax/Bak oligomerization and prevents mitochondrial outer membrane permeabilization (MOMP) with IC50 of 4 uM. |
| PC-60927 |
FX1
BCL6 inhibitor
|
FX1 (BCL6 inhibitor FX1) is a potent, specific BCL6 BTB domain inhibitor with Kd of 7 uM, binds with a greater affinity than the natural BCL6 ligand SMRT (Kd=30 uM). |
