You are here:Home-Research Areas-Infection-HCV Infection

Request The Product List ofHCV Infection HCV Infection

Cat. No. Product Name CAS No. Information
PC-62103

ITX-5061 hydrochloride

1252679-52-9

ITX-5061 is a scavenger receptor B1 antagonist that promotes high-density lipoprotein (HDL) levels; inhibits SR-BI-dependent uptake of HDL-CE in transfected cells, decreases the fractional catabolic rate of HDL-CE and reduced its hepatic uptake in mice; inhibits HCVcc and HCVpp infection of primary human hepatocytes and/or human hepatoma cell lines and has minimal effects on HCV RNA replication.

HCV Infection

Phase 2 Clinical

PC-62102

ITX-5061

848144-15-0

ITX-5061 is a scavenger receptor B1 antagonist that promotes high-density lipoprotein (HDL) levels; inhibits SR-BI-dependent uptake of HDL-CE in transfected cells, decreases the fractional catabolic rate of HDL-CE and reduced its hepatic uptake in mice; inhibits HCVcc and HCVpp infection of primary human hepatocytes and/or human hepatoma cell lines and has minimal effects on HCV RNA replication.

HCV Infection

Phase 2 Clinical

PC-61440

Voxilaprevir

1535212-07-7

Voxilaprevir (GS-9857) is a potent HCV NS3/4A protease inhibitor that is used in combination with sofosbuvir and velpatasvir for treatment of HCV infection.

HCV Infection

Phase 2 Clinical

PC-35444

Coblopasvir

1312608-46-0 Coblopasvir (KW136, KW-136) is a novel HCV NS5A inhibitor under development for treatment of HCV infection.

HCV Infection

Phase 3 Clinical

PC-35056

Ciluprevir

300832-84-2 Ciluprevir (BILN2061) is a potent HCV NS3/4A protease inhibitor with Ki of 0.66 and 0.30 nM for NS3-NS4A protease of HCV 1b and HCV 1a, respectively; inhibits the replication of HCV replicon 1b and 1a with IC50 of 3 nM and 4 nM, respectively.

HCV Infection

Phase 2 Discontinued

PC-35011

Merimepodib

198821-22-6 Merimepodib (VX-497, VI-21497, MMPD) is a potent, selective, reversible, uncompetitive IMPDH inhibitor with broad-spectrum antiviral activity; inhibits HBV, HCMV, RSV and HSV-1 with IC50 of 0.4, 0.8, 1.1 and 6.3 uM, also inhibits BVDV, VEEV, Coxsackie B3 and Dengue virus with IC50 at low uM level; Merimepodib is 17- to 186-fold more potent than ribavirin against HBV, HCMV, RSV, HSV-1, parainfluenza-3 virus, EMCV, and VEEV infections in cultured cells, also demonstrates additivity when coapplied with IFN-alpha.

HCV Infection

Discontinued

PC-63573

MK-3281

886041-60-7 MK-3281 is a potent and orally bioavailable inhibitor of HCV NS5B polymerase with IC50 of 6 nM; MK-3281 is an equally potent inhibitor of gt 1a (EC50=28 nM), 1b BK (EC50=9 nM), and 3a (EC50=37 nM) replicons, shows 2 orders of magnitude less active on 2a (EC50=2018 nM) and 2b (EC50=1833 nM) replicons; demonstrates consistent decrease in viremia in vivo using the chimeric mouse model of HCV infection.

HCV Infection

Phase 1 Discontinued

Request The Product List

* Indicates a Required FieldYour information is safe with us.

  • *Product List:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Country:
  • Additional Information:
Contact Us sales@probechem.com