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Cat. No. Product Name CAS No. Information
PC-43527

Zatebradine

85175-67-3 Zatebradine (UL-FS49) is a potent blocker (antagonist) of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel, a specific bradycardic agent; blocks cardiac pacemaker current (If), decreases the rate of spontaneously beating guinea-pig atria with EC50 of 0.030 ug/mL.

Heart Failure

Discontinued

PC-43526

Zatebradine hydrochloride

91940-87-3 Zatebradine hydrochloride (UL-FS49) is a potent blocker (antagonist) of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel, a specific bradycardic agent; blocks cardiac pacemaker current (If), decreases the rate of spontaneously beating guinea-pig atria with EC50 of 0.030 ug/mL.

Heart Failure

Discontinued

PC-35441

Cimlanod

1620330-72-4 Cimlanod is a second-generation nitroxyl (HNO) donor.

Heart Failure

Phase 2 Clinical

PC-35298

FPL64176

120934-96-5 FPL64176 (ARC-64176) is a potent L-type Ca++ channel activator with EC50 of 16 nM; prolongs action potential duration and enhances contractility in guinea pig papillary muscle, induces contractile response with EC50 of 0.2 uM; produces biexponential tail current decays at -50 mV with fast and slow time constants of 4.30 +/- 0.30 and 44.52 +/- 4.56 msec, respectively; produces large increases in cardiac contractile force and diastolic blood pressure in anesthetized dogs (100 mg/kg, i.v.).

Heart Failure

Discontinued

PC-35055

Rimeporide

187870-78-6 Rimeporide (EMD87580) is a potent, selective sodium hydrogen exchanger NHE1 inhibitor, show promise as potential therapeutic agents for the treatment of heart failure.

Heart Failure

Discontinued

PC-63435

Neladenoson dalanate hydrochloride

1239235-25-6 Neladenoson dalanate is a potent, selective, orally acitve partial adenosine A1 receptor (A1AR) agonist (EC50=0.1 nM) for the treatment of chronic heart failure.

Heart Failure

Phase 2 Clinical

PC-63434

Neladenoson dalanate

1239309-58-0 Neladenoson dalanate is a potent, selective, orally acitve partial adenosine A1 receptor (A1AR) agonist (EC50=0.1 nM) for the treatment of chronic heart failure.

Heart Failure

Phase 2 Clinical

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